Xiaobin Zhang

xzhang56@wisc.edu

Post-Doctoral Researcher

Previous Education

B.S. in Pharmaceutical Sciences
Shandong Medical University, Ji’nan, China

M.S. in Pharmaceutical Sciences
Shenyang Pharmaceutical University, Shenyang, China

Ph.D. in Pharmaceutical Sciences
Peking University, Beijing, China

Hometown

China

Current Research

Eric Shusta Research Group
Novel Antibody-Transporter Conjugates for Brain Drug Delivery.

Previous Research Experience

University of Nebraska Medical Center
Postdoctoral research associate
Advisor: Alexander V Kabanov
Omaha, NE

Pluronic P85 is a synthetic amphiphilic block copolymer which inhibits Pgp efflux system in the blood-brain barrier (BBB) and enhances the delivery of Pgp substrates to the brain. Little is known about the effect of P85 on other transport system in the brain. The purpose of my work was to evaluate the effects of P85 on amino acid and organic anion transport in BBB. Primary bovine brain microvessel endothelial cells (BBMEC) grown on membrane inserts were used as an in vitro BBB model. Transporter expression was confirmed by reverse transcriptase polymerase chain reaction. BBMEC permeability studies were carried out in apical (AP) to basolateral (BL) and BL to AP directions. P85 had no effect on AP to BL transport of amino acids in BBMEC mode but induced plasma membrane depolarization and contribute to the effects of the copolymer on the energy-dependent transport systems.

Publications

  1. Zhang X., Alakhova DY, Batrakova EV et al (2008). Effect of Pluronic P85 on Amino Acid Transport in Bovine Brain Microvessel Endothelial Cells. J Neuroimmune Pharmacol. 3(4).

  2. Zhang, X., Xie, Y., Jin, Y. et al. (2004). The Effect of RMP-7 and Its Derivative on Transporting Evens Blue Liposome into Brain. Drug Delivery, 11(5), 301-309.

  3. Zhang, X., Yuan, S., Lei, P. et al. (2004). The Therapeutic Efficiency of Amphotericin B Liposome Modified by RMP-7 to Transport Drug across Blood Brain Barrier. Acta Pharmaceutica Sinica, 39(4), 292-295.

  4. Zhang, X. & Hou, X. (2003). Comparative Efficacy and Distribution of Evens Blue Liposome Modified by DSPE-PEG, Tween80 and Brij35. Journal of Chinese Pharmaceutical Science, 12(2), 71-75.

  5. Zhang, X., Xie, J., Li, S. et al. (2003). The Study on Brain Targeting of the Amphotericin B Liposomes. Journal of Drug Targeting, 11(2), 117-122.

  6. Zhang, X., Jin, Y., Xie, Y. et al. (2003). The Effect of RMP-7 and Its Derivative on the Transporting of Liposome into the Brain . Acta Pharmaceutica Sinica, 38(11), 867 – 870.

  7. Zhang, X., Xie, J., & Hou, X. (2003). The Effect Surfactants on the Properties of Amphotericin B Liposome. Acta Pharmaceutica Sinica, 38(6), 471-474.

  8. Zhang, X. & Hou, X. (2003). The Effect of Surfactants on the Properties of Evens Blue Liposome. Chinese Remedies & clinics, 3(1), 5-8.

  9. Zhang, X. & Hou, X. (2003). Advance in the Method to Mask the Taste of Drug. Chinese Journal of Hospital Pharmacy, 23 (1), 43-45.

  10. Zhang, X., Wang, X., Li, S. et al. (2002). Preparation of Liposomes Containing Evens Blue and Its Distribution in Mouse. Journal of Peking Uiversity (Health Science), 34(4), 362-364.

  11. Xie, Y., Ye, L., Zhang, X. et al. (2005). Transport of Nerve Growth Factor Encapsulated into Liposomes across the Blood–brain Barrier: In vitro and in vivo Studies. Journal of Controlled Release, 105(1-2), 106-119.

  12. Xie, Y., Ye, L., Zhang, X. et al. (2004). Establishment of an in vitro Model of Brain-blood Barrier. Journal of Peking Uiversity (Health Science), 36(4), 435-438.

  13. Wang, X., Li, S., Zhang, X., & Hou, X. (2003). Preparation of Thrombus Targeted Urokinase Liposomes and Its Thrombolytic Effect in Model Rats. Acta Pharmaceutica Sinica, 38 (3), 231-235.

  14. Li, S., Zhang, X., Wang, X. et al. (2002). Establishment of Microparticles by Electrostatic Interaction (In Chinese). Journal of Huazhong University of Science and Technology (Health Science), 31(6), 637-639.

  15. Li, S., Wang, X., Zhang, X. et al. (2002). Studies on the Alginate-chitosan Microcapsule and Renal Arterial Emboliaztion in Rabbits. Journal of Controlled Release, 84(1), 87-98.

  16. Wang, X., Li, S., Zhang, X. et al. (2002). The Effect of PEG-modified Liposome on Adriamycin Entrapment. Journal of Peking University, 34(3), 286-289.