Xin Xiang Wang

Ph.D. 2006

Research Project

I developed a combinatorial screening method to find out novel and better blood-brain barrier (BBB) drug delivery carriers. These carrier molecules are single-chain antibodies (scFv) which are displayed on the surface of yeast Saccharomyces cerevisiae (S. cerevisiae). In vitro cultured brain endothelial cells are contacted with scFv-displaying yeast cells, and they form robust conjugates if they have the correct antibody/antigen pairs. These conjugates are then separated from a large background of non-binding yeast cells. Hence, the binding yeast population harboring the potential carrier scFvs are enriched. These scFv clones are further evaluated for their ability to be internalized into and transcytosed across in vitro BBB models.

Previous Education

B.S. in Biochemical Engineering, English minor
Tianjin University, Tianjin, P.R. China


P.R. China

Previous Research Experience

Tianjin University
Biochemical Engineering Department
Undergraduate Research Advisor: Yan Sun
Hydrophobic Interaction Chromatography (HIC) of Bovine serum albumin (BSA). During this six-month research project, the governing parameters of the enrichment of BSA through HIC were studied.