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Blood-brain barrier genomics and proteomics

Genomic/transcriptomic and proteomic approaches can be used to extract global information about a system of interest. In particular, identification of BBB-specific gene expression can potentially identify molecular origins of phenotype and new targets for drug delivery. The brain microvasculature comprises only 10-3 parts of the total brain volume, so care needs to be taken to ensure that enough high quality messenger RNA is isolated. We have recently used laser-capture microdissection to compare brain microvessels from human and mouse brain specimens.

Representative Publications